There has through the course of the history of United States been a continually increasing regulatory web beating weaved. One area in which this has been prominent is in the field of firearms restrictions and registration. Even though the second amendment states that the right of the people “shall not be infringed” there seems to have been a significant amount of infringing by way of the government.
Regardless there appears to be a certain amount of push back from the states themselves. Mississippi is considering a Bill that would deny state assistance to the federal government. Specifically in matters regarding firearms. The bill says that the actors for the state directly or indirectly shall not enforce any federal statute that violates the Constitution of the United States or that of the state of Mississippi.
This bill falls short of explicitly nullifying federal provisions but is a nudge toward the use of nullification. It is possible that the state could completely go a bit further and completely disregard any legislation or regulation that it feels is in violation. There is a certain amount of utility in this form action. We have seen that with the legalization of marijuana across the country the federal government has began caving in and loosing its restrictions and enforcement with in the drug war.